Solute carrier family 22 (organic cation transporter),
member 1 (SLC22A1,
also called OCT1) is an important drug transporter mediating
the hepatic uptake of many commonly used drugs. Several SLC22A1 variants have functional consequences and have
been associated with altered disposition and response for drugs such as
metformin, imatinib, sorafenib, tropisetron, morphine and
tramadol.
We have published the
PharmGKB summary: very
important pharmacogene information for SLC22A1 in the Pharmacogenetics and Genomics Journal.
Find out more...
View our SLC22A1 VIP on PharmGKB.
Read our new publication:
PharmGKB summary: very
important pharmacogene information for SLC22A1
Goswami S, Gong L, Giacomini K, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Mar 27. [Epub ahead of print]
PMID:24681965
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