Wednesday, November 24, 2021
Tuesday, November 23, 2021
CPIC® Guideline for Potent Volatile Anesthetic Agents and Succinylcholine and RYR1 and CACNA1S update
Information about the update has been added to the CPIC RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine guideline page and the PharmGKB annotation for this guideline.
Monday, November 22, 2021
Thanks to user feedback regarding the PharmGKB pathways, we understand that many of our pathways are used for teaching and presentations, and that users love the detailed figures. We are also aware that many users are interested in the underlying data -- what's on the components tab, the papers supporting pathway arrows and the downloadable gpml file -- for doing further work with expression data or drug drug interactions. The detailed figures are a time consuming part of the life cycle of getting a pathway from first encounter of a paper with evidence to available on the PharmGKB website. Many pathways, including those from CPIC level A gene-drug pairs, do not yet have sufficient complexity for publication in peer reviewed journals. PharmGKB will continue to publish pathways with a lot of underlying data and those that people are willing to co-author and develop a rich text review in a peer reviewed journal with the detailed illustration. We are releasing a new feature for pathways that are in progress that will contain only the components tab and figure from the gpml. This will allow us to complete pathway updates more quickly as new candidates are published, and for users to see what's in progress. Some pathways will ultimately have the publication quality figures whereas others may not depending on demand or evidence. This will allow for more pathways to be available more quickly. We look forward to hearing back from the PharmGKB community at firstname.lastname@example.org.
Some examples to check out ...
In Progress: Cilostazol Pathway, Pharmacokinetics
In Progress: Febuxostat Pathway, Pharmacokinetics
In Progress: Paclitaxel Pathway, Pharmacokinetics
In Progress: Tamsulosin Pathway, Pharmacokinetics
In Progress: Ziprasidone Pathway, Pharmacokinetics
Tuesday, November 2, 2021
PharmGKB is wholly supported by NIH (NHGRI and NICHD). As we prepare for grant renewal, we are asking users of our API to provide us with 3-4 brief pieces of information to help us demonstrate the importance of our API to the global PGx community. If you use our API, please spend 1 minute filling out this survey.