Clinpharmpod is the clinical pharmacology podcast from the journal Clinical Pharmacology and Therapeutics produced in association with Nature Publishing Group. In the March 25th episode from Clinpharmpod, host Geoff Marsh interviews Dr. Mary Relling on the history and future plans for the Clinical Pharmacogenetics Implementation Consortium (CPIC). A joint effort between the Pharmacogenomics Research Network (PGRN) and PharmGKB, CPIC was established in 2009 to develop gene-drug dosing guidelines that enable the translation of genetic test results into actionable prescribing decisions. Dr. Relling addressed many questions regarding the origin of CPIC, the roles of CPIC members, how CPIC guidelines differ from other clinical guidelines, how gene/drug pairs are chosen and prioritized, the format and essential components of CPIC guidelines, and the future directions for CPIC.
PharmGKB has been intimately involved in the CPIC development from the very beginning. To date, twelve CPIC gene/drug guidelines have been published in journal Clinical Pharmacology and Therapeutics and a few more in the plan. All CPIC guidelines and updates are posted and maintained on PharmGKB in an interactive format. An article describing the CPIC guideline development process was also published recently in journal Current Drug Metabolism.