Vitamin D receptor (VDR) polymorphisms and treatment responses

The human VDR protein is trans-acting transcriptional factor. It binds the active form of vitamin D (1,25-dihydroxyvitamin D3) to modulate many biological activities of the neural, immune and endocrine systems. Poon et al. have recently written an updated Very Important Pharmacogene (VIP) Summary for VDR gene that is published in Journal Pharmacogenetics and Genomics.

Due to the pleiotropic effect exerted by the 1,25-dihydroxyvitamin D3–VDR complex, genetic variants in VDR have been found to be associated with a wide variety of diseases and phenotypes, including various cancer, asthma, calcium absorption, bone mineral density (BMD) and hyperparathyroidism. They have also been linked to therapeutic responses to vitamin D and calcium supplements, antiresorptive treatments, calcipotriol and dexamethasone.

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View our new VDR VIP with links to important variants, associated drug responses, mapping and publications.

Read our new VDR VIP Summary publication.