The current Curators Favorite Papers are selected around pharmacogenetics of smoking cessation and nicotine metabolism. The review by Gold & Lerman [PMID: 22290489] discusses evidence for the association of cholinergic and nicotine metabolism gene variations with smoking cessation and therapeutic response. The article by Binnington et al. [PMID: 22569203] studied variants in the CYP2A6 and CYP2B6 gene in association with nicotine metabolism in Alaska Native people. The role of the CYP2A6 gene and its variation in the metabolism of several drugs is summarized in the review by McDonagh et al. [PMID: 22547082].
The PharmGKB Pharmacokinetic and Pharmacodynamic
Nicotine Pathways illustrate where the above mentioned gene are involved in nicotine metabolism and action.
