Monday, October 8, 2018

PharmGKB oxycodone pathway published in Pharmacogenetics and Genomics


The PharmGKB Oxycodone Pathway, Pharmacokinetics is featured on the cover of the October 2018 issue of Pharmacogenetics and Genomics. Oxycodone is an opioid analgesic metabolized by CYP2D6 and CYP3A4/5 to a number of metabolites, including oxymorphone which itself can be used as an analgesic.

The pathway was produced by scientific curator Dr. Rachel Huddart in collaboration with Dr. Melissa Clarke of the Medical Home Development Group and Whole Genome Science Foundation. It discusses the current state of knowledge of both the pharmacokinetics and pharmacodynamics of oxycodone as well as pharmacogenetic research into the drug. Oxycodone is covered by a DPWG guideline, an annotated version of which can be found on the PharmGKB website. You can access the Oxycodone Pathway, Pharmacokinetics on the PharmGKB website here.

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