Friday, September 14, 2018

CYP2D6 genotype to phenotype standardization project - seeking feedback

The assignment of the CYP2D6 metabolizer phenotype based on a subject's genotype is an important aspect of clinical implementation of pharmacogenetics knowledge. Especially for CYP2D6, the genotype-inferred phenotypes vary across laboratories and guidelines. The goal of the CYP2D6 genotype to phenotype standardization project is to harmonize this translation. 

The following consensus was reached by a group of CYP2D6 excepts through a series of surveys:
1) Activity score of 1 should be assigned as CYP2D6 intermediate metabolizer
2) Downgrading the CYP2D6*10 allele from activity score 0.5 to 0.25

We are seeking feedback on the final CYP2D6 genotype to phenotype table, which summaries all CYP2D6 metabolizers assignment based on activity score. 

Information about the project are available herehttps://cpicpgx.org/resources/cyp2d6-genotype-to-phenotype-standardization-project/. Please email any comments to contact@cpicpgx.org by September 27th.
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