NIGMS Director’s Early Career Investigator Lecture on antiretrovirals, PGx

On Wednesday, April 5th at 2:00 PM EST the National Institute of General Medical Sciences (NIGMS) will broadcast the NIGMS Director’s Early Career Investigator Lecture featuring a talk by Dr. Namandjé N. Bumpus entitled “Drug Metabolism, Pharmacogenetics and the Quest to Personalize HIV Treatment and Prevention”. In it, she will discuss her work on the factors that impact metabolism and distribution of antiretrovirals and their effect on outcomes in HIV-positive individuals. Dr. Bumpus’ research attempts to integrate a mechanistic understanding of the metabolism and distribution of antiretrovirals in cells and tissues in order to enable the prediction of patient response. Dr. Bumpus is an Associate Professor of Medicine at Johns Hopkins University School of Medicine, as well as an associate editor of the journal Drug Metabolism and Disposition. 

The video cast of the lecture may be accessed below:

https://www.nigms.nih.gov/News/meetings/Pages/2017-eci.aspx

Variant and clinical annotations for antiretrovirals used in HIV treatment are available at PharmGKB. Curated pathways are also available for the following: 

• efavirenz 
• tenofovir 
• lamivudine 
• nevirapine 
• zidovudine 
• abacavir 
• nevirapine

Pharmacogenetically-guided dosing and prescribing guidelines for abacavir and atazanavir are both available at cpicpgx.org and PharmGKB.