Translating
pharmacogenomics knowledge into clinical practice has not been an easy task.
Barriers that prevent the widespread use of PGx diagnostics include the lack of
incentives for health care systems to conduct tests as well as lack of clear
clinical guidelines for translating genetic variations into actionable
recommendations. Additionally, computational tools for clinical decision
support (CDS) will need to be developed and integrated in the EHR to prompt and
guide clinicians on how to use genetic information when prescribing drugs. CPIC was formed in 2009 as a
collaborative project between PharmGKB and the Pharmacogenomics ResearchNetwork to address some of the challenges in clinical implementation. Its goal
was to create guidelines to aid clinicians on how genetic test results should
be translated into specific prescribing actions. CPIC guidelines are
simultaneously published and maintained on PharmGKB website, in both plain text
as well as computable form for easy integration into clinical decision support
tools. Many of the CPIC guidelines have been endorsed by professional societies
such as The American Society of Health-System Pharmacists (ASHP). CPIC have
also established informatics subgroup to support the adoption of the CPIC guidelines by developing tools
to combine clinical information from the EHR with the information from the CPIC
guidelines and use them for clinical decision support. Preemptive pharmacogenomic testing programs using EHRs and
decision support tools have been deployed at several academic medical centers,
eg. St. Jude, Vanderbilt University and University of Florida.
Read
the GenomeWeb article:
Read
the press release from Genelex:
More
information about CPIC and CPIC informatics working group:
https://cpicpgx.org/informatics/
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