Cytochrome p450,
family 2, subfamily F, polypeptide 2 (CYP4F2) is known to catalyze multiple
biological reactions. It is
predominantly expressed in the liver and kidneys, although there is evidence
that it is also expressed in the intestines. Of specific interest in pharmacogenetics, hepatic
CYP4F2 regulates the bioavailability of vitamin K and vitamin E and is currently studied to determine how
polymorphisms in CYP4F2 affect warfarin
dosing in patients. A single variant in CYP4F2 (rs2108622) is significantly
associated with small, but significant alterations in warfarin dosage in Asian
and Caucasian populations.
For more information on
this VIP gene and variant, please see the VIP tab for CYP4F2.
