The review summarizes the important role NAT2 plays in the metabolism and detoxification of many therapeutic drugs, and why genetic variants within the NAT2 gene are associated with drug-induced toxicity as well as cancer. Associations between drug responses and important NAT2 variants are detailed, and possible reasons behind a lack of consistency for some associations are discussed.
> View an interactive version of the NAT2 VIP summary on PharmGKB.
> Read the article:PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.
McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE.
Pharmacogenetics & Genomics. 2014 Jun 2. (Epub ahead of print)
|NAT2 genetic variants have been linked to drug-induced hepatotoxicity|