To apply, search for Scientific Curator - 61462 under Staff Positions at jobs.stanford.edu
· Read pharmacogenomic experimental literature,
analyzing articles for details about gene variant-drug relationships to enter
into PharmGKB database; interpret results and conclusions from this literature
and summarizes these for PharmGKB. This
may involve searching other public genomics databases, making inferences, and
mapping variant locations between genomic sequences and unique assigned
identifiers.
· Evaluate and synthesize evidence extracted
from primary pharmacogenomic literature as above, including contradictory results,
and write conclusions about the effects of particular genotypes upon response
to specific drugs.
· Create drug pharmacokinetic and pharmacodynamics
pathways based on evaluation of literature using PharmGKB proprietary software and
writes a detailed description of the pathway process, alone or in collaboration
with domain experts, that is published both online and in a peer-reviewed journal.
· Write detailed literature review of
important pharmacogenetics genes (VIPs), alone or in collaboration with domain
experts, that is published both online and in a peer-reviewed journal.
· Co-author CPIC genotype-based drug
dosing guidelines for peer-reviewed publication. Literature reviews, provide background
information and manuscript writing.
· Participate in scientific data
consortia- helps to design data collection forms; consolidate and curate
primary data from individual labs; work with developer to design QC tests for
data; communicate with other scientists about data discrepancies/questions and
standards for data inclusion; help with manuscript preparation for
publication.
· Support all scientific needs of
PharmGKB, including but not limited to PGx summaries, drug label curation, curating
gene haplotype and phenotype definitions, drug-gene relationships, curation of
NLP relations for incorporation into the curation workflow, handling of rare
variants, blogging, genome annotations and PharmGKB recommendations for
clinical use of variant-drug pairs.
Attend and present at scientific meetings and present academic lectures
as needed.
· Work with curation and development
teams to design, improve and test new website functionality and UI for
PharmGKB. Report issues with existing functionality
and suggest improvements or new features.
· Interact and respond as required to
funding agencies, FDA, feedback, etc.
· Any and all other curator projects as
they arise.
