CYP2C8 is a member of the cytochrome P450 family of drug metabolizing enzymes. It plays a major role in the metabolism of many commonly used drugs. Several CYP2C8 SNPs have been associated with variability in metabolism, disposition and response for drugs such as repaglinide, rosiglitazone, pioglitazone, paclitaxel, bisphosphonates, amiodarone and amodiaquine. We have recently published the CYP2C8 pharmacogenomic summary in Journal Pharmacogenetics and Genomics.
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PharmGKBsummary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8
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