We have added two new pathways to our collection, in collaboration with Dr. Christine Staatz from the University of Queensland and Dr. Raman Venkataramanan from the University of Pittsburgh. These pathways cover the pharmacokinetics and pharmacodynamics of tacrolimus and cyclosporine. Both drugs are immunosuppressants given to solid organ transplant recipients in order to prevent allograft rejection. They differ in structure, but have highly similar metabolisms and immunosuppressive actions. Given these similarities, the drugs are combined on the pharmacokinetic and pharmacodynamic pathways. The pharmacokinetics pathway shows the metabolism of these two drugs and the genes and cells involved, and the pharmacodynamics pathway shows the mechanisms by which the drugs inhibit immune responses within T cells.
A large number of genes are involved in the pharmacogenetics of these drugs. Please visit the tacrolimus/cyclosporine pharmacokinetics or tacrolimus/cyclosporine pharmacodynamics pathway pages to find out more and to view or download these pathways.
View all pathways at PharmGKB