We have added two new pathways to our collection, in
collaboration with Dr. Christine Staatz from the University of Queensland and
Dr. Raman Venkataramanan from the University of Pittsburgh. These pathways cover
the pharmacokinetics and pharmacodynamics of tacrolimus and cyclosporine. Both
drugs are immunosuppressants given to solid organ transplant recipients in
order to prevent allograft rejection. They differ in structure, but have highly
similar metabolisms and immunosuppressive actions. Given these similarities, the
drugs are combined on the pharmacokinetic and pharmacodynamic pathways. The
pharmacokinetics pathway shows the metabolism of these two drugs and
the genes and cells involved, and the pharmacodynamics pathway shows the
mechanisms by which the drugs inhibit immune responses within T cells.
A large number of genes are involved in the pharmacogenetics
of these drugs. Please visit the tacrolimus/cyclosporine pharmacokinetics or
tacrolimus/cyclosporine pharmacodynamics pathway pages to find out more and to view or
download these pathways.
View all pathways at PharmGKB
