Wednesday, April 17, 2013

Clinical notes used for pharmacovigilance

A team at Stanford University have computationally extracted information from free-text clinical notes in medical records, in order to identify drug-induced adverse events and adverse reactions from drug-drug interactions. Information from the notes was deidentified and transformed into a patient-feature matrix using a medical ontology hierarchy system. They demonstrate that the method could be used to flag potential adverse reactions earlier than FDA alerts are reported by current methods.

Read More:
Pharmacovigilance Using Clinical Notes
Lependu P, Iyer SV, Bauer-Mehren A, Harpaz R, Mortensen JM, Podchiyska T, Ferris TA, Shah NH. 
Clin Pharmacol Ther. 2013 Mar 4. doi: 10.1038/clpt.2013.47.