Curators' Favorite Papers

The current Curators' Favorite Papers are about pharmacogenomics of antidepressant drugs. Narasimhan and Lohoff review recent findings on the pharmacogenetics of antidepressant drugs and discuss possible future clinical implementations [PMID: 22380000]. The study by de Klerk et al. investigates the association of ABCB1 variants with adverse effects of antidepressants in a large cohort of patients with major depressive disorder. The authors report a significant association between the number of selective serotonin reuptake inhibitors-related adverse drug effects and two ABCB1 SNPs (rs2032583 and rs2235040) [PMID: 22641028]. Sasayama et al. present evidence that polymorphisms in the CUX1 gene (rs365836 and rs201522) may be associated with response to antidepressant treatment based on a genome-wide approach followed by a candidate SNP analysis [PMID: 22584459].