New VIP gene summary for CYP2E1

A new VIP summary is available for CYP2E1, a member of the cytochrome P450 family of drug metabolizing enzymes. CYP2E1 is constitutively expressed in the liver but makes up less than 1% of the total hepatic P450 isoforms [Article: 20100563]. It metabolizes relatively few prescription drugs (approximately 2%), however its important in the toxicity of acetaminophen, the antituberculosis drug isoniazid, and the probe drug and muscle relaxant chlorzoxazone [Article: 18695978]. Pathways for acetaminophen and isoniazid are in development and will be released soon ( NEW: Acetaminophen Pathway, Pharmacokinetics is released 1/16/2013). 

For more information on this VIP gene and its variants see the VIP tab for CYP2E1

PharmGKB welcomes Ugur Hodoglugil to the team

We are pleased to welcome scientific curator Ugur Hodoglugil to the PharmGKB team. Previously, Ugur has worked as research scientist on identifying the genetic determinants of complex traits (lipid and other metabolic phenotypes) and population structure at Gladstone Institutes, University of California San Francisco where he analyzed genome-wide scans data for quantitative trait locus analysis in families and studied the effects of variations of several candidate genes on lipid metabolism in unrelated individuals. He  performed different assays with transgenic/knockout mice and cell culture experiments to show functionality of the variants or the phenotype of gene(s) of interest. He has obtained his M.D. and Medical Pharmacology, Ph.D. degrees from Ankara, Turkey.

New PGRN Featured Project and PI for the Month of November

The PGRN website is featuring a new project and investigator of the month from the PAT (Pharmacogenomics of Arrhythmia Therapy) group.

For detailed information, please visit the PGRN website.

From Genomics & Informatics to Precision Medicine

Several PharmGKB curators plan to attend UCSF's Institute for Human Genetics 2012 Symposium on Monday 5th Nov, entitled "From Genomics and Informatics to Precision Medicine".

Speakers include those from Genentech, Kaiser Permanente and prominent universities in the USA.

We hope to see you there!

PharmGKB team celebrates Halloween

The PharmGKB team joined the Halloween celebrations this week - take a look at our pumpkin carving skills!

ASHG Annual Meeting 2012 (6th-10th Nov)

The PharmGKB curators will be attending the American Society of Human Genetics Annual Meeting in San Francisco next week and look forward to a week of interesting talks and posters.

On Thursday 8th November (2:15-3:15pm) we will be presenting two posters - one focusing on the pharmacogenomic research undertaken by PharmGKB consortia, and the other focusing on the clinical interpretation and implementation of pharmacogenomics knowledge.

We hope to see you there!