ClinPGx Sessions at PGRN 2023 Conference and ClinGen Summer Workshops

At the upcoming PGRN 2023 annual conference in Memphis, Dr. Teri E. Klein, the principle investigator for PharmGKB, ClinGen, CPIC and PharmCAT,  will hold a town hall discussion on ClinPGx: a single integrated resource for Pharmacogenomics (PGx). Dr. Klein will discuss the challenge of the separation of pharmacogenomic resources from clinical genomic resources, and present a long-term, conceptual framework for broadly integrating the available PGx resources into a single resource, ClinPGx. 

Dr. Klein will also present at the upcoming ClinGen 2023 Summer Workshop Series on June 16 11am PT. Please come join us. We are actively seeking feedback from the PGx and genomics community on the interest and development of ClinPGx to facilitate the incorporation of PGx into standard of care. Zoom link below: 

June 16th, 2023, 11am PT/ 2pm ET 

Join Zoom Meeting : 

https://acmg.zoom.us/j/87027015818?pwd=S2U2OTFhQ1oranFZZjNlTEhHN0FlUT09 

Meeting ID: 870 2701 5818 

Passcode: 83854960 

One tap mobile 

+16699006833,,87027015818# US (San Jose) 

+17193594580,,87027015818# US 

ClinGen Pharmacogenomics Working Group (PGxWG) Survey Open Until June 30, 2023

The ClinGen Pharmacogenomics Working Group (PGxWG)'s anonymous survey is OPEN until June 30, 2023. Our goal is to gather opinions and feedback regarding the criteria and terminology that should be used to define clinical validity and actionability for pharmacogenes and variants. Please help disseminate to ALL (clinicians, pharmacists, labs, genetic counselors, etc.). We are looking for BROAD global participations - please send to your friends and colleagues too!  If you’ve previously completed the survey, we appreciate your contribution and there's no need to submit a second response. 

The survey can be accessed at: https://stanforduniversity.qualtrics.com/jfe/form/SV_1IdrrPWBXsV2Xt4.  We sincerely appreciate your time and participation, and your willingness to help.

ClinGen Pharmacogenomics Working Group (PGxWG) Follow-Up Survey

The ClinGen Pharmacogenomics Working Group (PGxWG) has just launched a second survey to solicit feedback about the criteria and terminology that should be used to define clinical validity and actionability for pharmacogenes and variants from both the PGx community and the wider genetics and medical communities. Please note that this second survey is not independent of the first, and if you’ve taken the previous survey and have significant PGx familiarity or expertise, there is no need to take this iteration, as it would be redundant due to the overlap in questions.

The ClinGen PGxWG is a multi-disciplinary team of researchers and professionals with expertise in pharmacogenomics (PGx), clinical pharmacology, medical genetics, regulatory affairs, and molecular diagnostics. It was launched in February 2022 with the goal of developing a framework of tiered standard terminology and definitions that reflect clinical significance for genes and genomic variants implicated in drug response, in order to facilitate the incorporation of PGx knowledge into ClinGen and more consistent interpretation of PGx variants identified by panel testing and/or sequencing.

The survey is open now and can be accessed at: https://stanforduniversity.qualtrics.com/jfe/form/SV_1IdrrPWBXsV2Xt4. All responses are greatly appreciated, no matter who you are or where you are in the world. Unlike the previous survey, this survey does not assume PGx familiarity, though if you have not taken the previous survey and have PGx familiarity, your feedback is still greatly appreciated. The survey takes approximately 15 minutes to complete. We sincerely appreciate your time and attention, and your willingness to help.

ClinGen Pharmacogenomics Working Group (PGxWG) Survey

The ClinGen Pharmacogenomics Working Group (PGxWG) has launched a survey to solicit feedback about the criteria and terminology that should be used to define clinical validity and actionability for pharmacogenes and variants. 

The ClinGen PGxWG is a multi-disciplinary team of researchers and professionals with expertise in pharmacogenomics (PGx), clinical pharmacology, medical genetics, regulatory affairs, and molecular diagnostics. It was launched in February 2022 with the goal of developing a framework of tiered standard terminology and definitions that reflect clinical significance for genes and genomic variants implicated in drug response, in order to facilitate the incorporation of PGx knowledge into ClinGen and more consistent interpretation of PGx variants identified by panel testing and/or sequencing.

The survey is open now and can be accessed at: https://stanforduniversity.qualtrics.com/jfe/form/SV_bKqeKf2YmCVS1LM.  All responses are greatly appreciated, no matter who you are or where you are in the world. This survey does assume some PGx familiarity, though we plan to launch another survey targeting those with less PGx experience in the near future. The survey takes approximately 10 minutes to complete. We sincerely appreciate your time and attention, and your willingness to help.

PharmGKB selected in the first list of Global Core Biodata Resources

We are pleased to announce that PharmGKB is included in the first list of Global Core Biodata Resources (GCBRs), a collection of resources whose long term funding and sustainability is critical to life science and biomedical research worldwide.

The Global Biodata Coalition (GBC) brings together major public and charitable funders, with the aim to “stabilize sustainable financial support for the global biodata infrastructure and in particular to identify for prioritized long-term support a set of Global Core Biodata Resources that are crucial for sustaining the broader biodata infrastructure.” After a rigorous two-stage process evaluating scientific quality and impact, 37 resources were selected in the first list of GCBRs. One key feature of the GCBRs is that the data from these resources are available openly and can be accessed and used without restriction by researchers worldwide. PharmGKB is honored to be recognized as a Global Core Biodata Resource and we fully support GBC's mission to stabilize support for the global biodata infrastructure.

We would like to take this opportunity to thank all the present and past members of PharmGKB, our funding agencies, scientific advisors and collaborators, and especially our users, for their continued support and contribution to build this vital resource. PharmGKB serves both basic science investigators as well as clinicians and laboratories. Sustainable long-term support is critically important for us to provide stable, comprehensive, and dependable pharmacogenomic information to our users across the globe.

New tutorial and walkthrough videos now available

We are pleased to announce the release of our PharmGKB walkthroughs and tutorial videos on YouTube. Users can now view detailed video walkthroughs of each of the main annotation types on PharmGKB as well as a longer video combining resources from across the site. We have also produced a series of tutorial videos to help users learn more about key concepts and issues in pharmacogenomics. These videos range from an introduction to the field to an explanation of the star allele nomenclature system for haplotypes. The videos are freely available on the PharmGKB YouTube channel. Links can also be found on our Educational Resources page. 

Ask a Curator for Healthcare Professionals on June 7th

We are holding an Ask a Curator zoom targeted towards healthcare professionals wanting to learn more about PharmGKB and pharmacogenomics. This is part of NHGRI’s Healthcare Professionals Genomics Education Week (#MedGeneEd22). Be sure to spread the word to colleagues who may find this useful.

We are asking people to please register in advance with their questions so curators can better focus these events. There will also be the opportunity to ask questions during the event. Events will be limited to 25 participants to allow enough time for everyone’s questions to be answered.

Sign up here for Tuesday June 7th at 12pm EST, 9am PST, 5pm GMT
Want to be notified about future Ask a Curator events? Join our mailing list here.

"Ask a Curator" live zoom event

PharmGKB curators will hold a series of live Q&A events over Zoom to help people find and use different aspects of the knowledgebase. We hope this will be a great way to answer questions about PharmGKB and PGx which are specific to users’ individual needs or projects.  These events will demonstrate the full extent of the resources available on PharmGKB, as well as details about those resources and how to download, use, and cite data from PharmGKB. 

In order to tailor these events for users with similar needs from PharmGKB, the first event will focus on researchers. Future events geared towards educators and clinicians are in the works, as well as events hosted at different times for our global audience. We will also be recording this upcoming event along with future events for those who are unable to attend live. Recordings will be posted on the PharmGKB YouTube channel.

We are asking people to please register in advance with their questions so curators can better focus these events. There will also be the opportunity to ask questions during the event. Events will be limited to 20 participants to allow enough time for everyone’s questions to be answered.

Sign up here for Tuesday April 26th at 12pm EST, 9am PST, 5pm GMT

Can’t make it but want to sign up for a future Ask a Curator? Join our mailing list here.

NHGRI/NCI survey on genomics education

The National Human Genome Research Institute (NHGRI), who are supportive of PharmGKB and CPIC, have teamed up with the National Cancer Institute (NCI) to survey research and healthcare professionals about genomics education. The results of this survey will help to determine the resource and training priorities for future genomics education.

PharmGKB and CPIC are both actively working on pharmacogenomic education initiatives and we encourage everyone working in pharmacogenomics to complete the survey. This will highlight the importance of pharmacogenomics in future genomics education.

The survey takes approximately 10 minutes to complete and is tailored to different roles in both research and healthcare. The questions aim to evaluate respondents’ knowledge of genomics and learning needs. It will also help to identify barriers to accessing genomics education as well as preferred training methods.

The survey is open now and can be accessed at https://www.surveymonkey.com/r/GenomicEducation until September 15. All responses are anonymous and the results will be presented at the NHGRI meeting on September 25-26.

PharmGKB Demo at U-PGx Summer School

PharmGKB recently held a demonstration of the PharmGKB website as part of the U-PGx Summer School in Bonn, Germany. Scientists, clinicians and pharmacists attending the summer school heard from Dr. Rachel Huddart, one of our Scientific Curators, and were introduced to the various types of information found on the PharmGKB website; from Dosing Guidelines to Pathways and Clinical Annotations. Information from PharmGKB formed an important of the participants’ project work later on in the summer school.

The U-PGx summer school group sees PharmGKB in action

 

This was a remote demonstration, with Rachel presenting at the summer school online from our Stanford offices. If you are interested in including a demonstration of the PharmGKB website at your pharmacogenomics event, please get in touch with us at feedback@pharmgkb.org.