Thursday, January 28, 2016

January SNPits Summary

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The January issue of SNPits, the University of Florida’s Personalized Medicine Program e-newsletter, summarizes pharmacogenetics studies. ...
Tuesday, January 19, 2016

The Pharmacogenetic Phenome Compendium, A Chemical–Genetic Interaction Map

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Development of new drugs is a complicated and difficult process, with many initially promising compounds falling by the wayside due to unfor...
Thursday, January 14, 2016

Constellation: tool for automated CYP2D6 phenotype assignment from WGS

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A team  from Children’s Mercy  and the University of Missouri  in Kanas City  including Andrea Gaedigk and Greyson Twist  published an arti...
Wednesday, January 13, 2016

Cisplatin FDA label changes

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In 2013 we blogged about the controversy with the FDA labeling for cisplatin and its warning for TPMT variants and increased risk ...
Sunday, December 20, 2015

ACMG Issues a Revised Position Statement Regarding DTC Genetic Testing

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The American College of Medical Genetics (ACMG) recently revised its position statement regarding direct-to-consumer (DTC) genetic testing. ...
Thursday, December 17, 2015

DIGITizE Suggests Implementing 2 CPIC Guidelines in CDS

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The DIGITizE Action Collaborative has suggested that Clinical Decision Support (CDS) be implemented based on CPIC's TPMT/azathioprine an...
Friday, December 11, 2015

Combining large PGx datasets from cancer cell lines

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Testing cancer cell lines in vitro for drug sensitivity is a cornerstone of preclinical drug development. Large publically availab...