Monday, May 11, 2015

New CPIC Guideline: CYP2D6 and CYP2C19 and Selective Serotonin Reuptake Inhibitors

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Guidelines by the Clinical Pharmacogenetics Implementation Consortium ( CPIC ) regarding the use of pharmacogenetic tests for CYP2D6 and CY...
Tuesday, April 21, 2015

GWAS on SSRI treatment outcome in patients with depression: ISPC cohort and meta-analysis

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The treatment response to selective serotonin reuptake inhibitors (SSRIs), a major class of antidepressant drugs, varies considerably ...
Tuesday, March 31, 2015

PharmGKB and Stanford Law School student collaboration

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The Stanford Law School blog recently highlighted the collaboration between Stanford law students and PharmGKB to write a response to the FD...
Friday, March 27, 2015

NAT2 plays a role in insulin sensitivity

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N-acetyltransferase 2 (NAT2) has long been known to metabolize xenobiotics but the endogenous substrates of NAT2 remain unknown. A new s...
Thursday, March 26, 2015

New CPIC Guideline: CYP3A5 and Tacrolimus

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Guidelines regarding the use of pharmacogenetic tests for CYP3A5 in dosing tacrolimus have been published in Clinical Pharmacology and Ther...
Thursday, March 5, 2015

ABCB5 and haloperidol-induced toxicity: Results from a new study

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Approximately 50% of patients treated with the antipsychotic drug haloperidol will develop extrapyramidal symptoms, a category that includes...
Wednesday, February 25, 2015

Our 10-step guide to enabling your PGx study to be curated

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At PharmGKB we manually curate pharmacogenetic (PGx) associations found in published articles and add them to our database. However, lack of...