Tacrolimus and cyclosporine are two immunosuppressants given to solid organ transplant patients to prevent allograft rejection. A PharmGKB summary discussing the pharmacokinetics, pharmacodynamics and pharmacogenetics of these two drugs has been published in Pharmacogenetics and Genomics, and is now available to read online ahead of print. The summary also includes two comprehensive pathway diagrams covering the pharmacokinetics and pharmacodynamics of the drugs.
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PharmGKB summary: cyclosporine and tacrolimus pathways.
Barbarino JM, Staatz CE, Venkataramanan R, Klein TE, Altman RB
Pharmacogenet Genomics. 2013 Aug 5.