Tailored second line therapy in asthmatic children with the arginine-16 genotype. Lipworth BJ, Basu K, Donald HP, Tavendale R, Macgregor DF, Ogston SA, Palmer CN, Mukhopadhyay S. Clinical Science (2013) 124, (517-519).
This trial was based on previous studies from the same group showing an increased risk of asthma exacerbations in children with daily exposure to beta2-adrenergic receptor agonists who have the ADRB2 Arg16 variant:
- "Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol" Palmer et al, (2006).
- "Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol" Basu et al, (2009).
Learn more about Beta-agonist action on ADRB2:
Learn more about the ADRB2 gene:ADRB2 Very Important Pharmacogene summary